科技处9月1日讲座----中国科学院北京基因组研究所

CV:
University of Science and Technology of China (USTC), B.S., 1994.
Massachusetts Institute of Technology, Ph.D., 2000.
Harvard University, Postdoctoral Fellow, 2000-2002.
University of Chicago,
Assistant Professor 2002-2008.
Associate Professor 2008-2010.
Professor 2010-

RESEARCH INTERESTS:

Our research program spans a broad range of chemistry, chemical biology, microbiology, bioinorganic chemistry, cell biology and structural biology. We probe the pathways and mechanisms of DNA/RNA repair and modification. We work on virulence and antibiotic resistance regulation in human pathogens, and develop new antibiotics. We study selective metal ion recognition and sensing by naturally occurring and engineered proteins. We also explore metal-catalyzed organic transformations.

Selected References

Yang, C.-G.; Yi, C.; Duguid, E. M.; Sullivan, C. T.; Jian, X.; Rice, P. A. and He, C.* “Crystal Structures of DNA-RNA Repair Enzymes AlkB and ABH2 Bound to dsDNA” Nature, 2008, 452, 961-965.

Chen, P.; Bae, T.; Williams, W. A.; Duguid, E. M.; Rice, P. A.; Schneewind, O. and He, C.* “An Oxidation Sensing Mechanism is Used by A Global Regulator of Staphylococcus aureus” Nature Chem. Biol. 2006, 2, 591-595.

Chen, H.; Hu, J.; Chen, P. R.; Lan, L.; Li, Z.; Hicks, L. M.; Dinner, A. R. and He, C.* “The Pseudomonas aeruginosa Multidrug Efflux Regulator MexR Uses An Oxidation Sensing Mechanism” Proc. Natl. Acad. Sci. 2008, 105, 13586-13591.

Chen, C.-S.; Karabkova, E.; Chen, H.; Jian, X.; Zhu, J.; Tao, S.-C.; Hu, S.; He, C.* and Zhu, H.* “A Proteome Chip Approach Reveals New DNA Base Damage Recognition Activities in Escherichia coli” Nature Methods, 2008, 5, 69-74.

Chen, P. R. and He, C.* “Selective Recognition of Metal Ions by Metalloregulatory Proteins” Curr. Opin. Chem. Biol. 2008, 12, 214-221.

Li, Z.; Capretto, D. A. and He, C.* “Gold Catalyzed Organic Transformations” Chem. Rev. 2008, 108, 3239-3265.

顺义园区参加讲座者交通自理。
－－－－－－－－－－－－－－－－－－

Welcome to attend!